![]() In this experiment, 50µM DIM inhibited biofilm growth by 65% and 70%, respectively. aeruginosa, both of which are multi-drug resistant and therefore clinically important. would be nice to see if these data are similar in other important and gram-positive bacteria such as Staphylococcus aureus.”įollowing their initial findings, the researchers then focused on A. “Biofilm formation was markedly inhibited by DIM in two of the pathogenic bacteria studied. Satola told Medical News Today she would like to see more investigations: In all four bacteria, DIM reduced the biofilm formation by up to 80%.ĭr. Gram-negative bacteria have a high resistance to antibiotics. The researchers investigated four gram-negative pathogenic bacteria - Pseudomonas aeruginosa PAO1, Acinetobacter baumannii, Serratia marcescens, and Providencia stuartii strains. Sarah Satola, associate professor of medicine and infectious Diseases, director at Emory University School of Medicine’s Investigational Clinical Microbiology Core The longer a bacteria is exposed to the antibiotic, the greater the risk of the bacteria becoming heteroresistant or even resistant.” Treating an infection that has formed a biofilm, and the source of the biofilm may require a longer course of an antibiotic(s). “The ability to safely disrupt a bacterial biofilm has the potential to reduce antibiotic resistance. ![]() In this study, researchers investigated the effects of DIM on biofilms formed by pathogenic bacteria.
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